Indication & Dosage |
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| Oral |
| TREATMENT OF HYPERCHOLESTEROLAEMIA (TYPES IIA AND IIB) |
| Adult:
As sodium: Initially, 100 mcg once daily at night adjusted to 100 mcg increments at min of 4-wk intervals. Max dose: 300 mcg daily. |
| Max Dosage: with severe renal impairment is 200 mcg once daily. |
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| Precautions |
Severe renal impairment. Monitor liver function. |
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Potentially Life-threatening
Adverse Drug Reactions |
GI disturbances, dysgeusia; headache, dizziness, insomnia; rashes; blurred vision. |
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| Adverse Drug Reactions |
Hepatitis, pancreatitis, rhabdomyolysis. |
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| Interactions |
Concurrent admin with immunosuppressants, fibric acid derivatives, nicotinic acid increase risk of myopathy. Increased bleeding with anticoagulants. Raised plasma conc with mibefradil. |
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